Effect of Pawpaw Seeds on Management of Alloxan-Induced-Diabetes in Rats

Ethanol extract of pawpaw seed was evaluated for a possible application in the management diabetes. Alloxan used to induce diabetes rats, which were subsequently study antihyperglycaemic effect extract. Four (4) treatment groups and two (2) control 8 rats each created using complete randomized design. Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low-density (LDL), protein (TP), glutamic oxaloacetic transaminase (SGOT/AST), pyruvic (SGPT/ALT), alkaline phosphatase (ALP), urea creatinine studied standard methods. A single dose alloxan resulted significant increase (p < 0.05) serum TG, TC, LDL, AST, ALT, ALP, with corresponding decrease HDL, creatinine. Following varying doses extract, there an It could be inferred from research outcome that crude (200 mg/kg extract) effective